SISSA Open Science

Polymorphism and bistability in adherent cells

Show simple item record Shiladitya Banerjee Luca Giomi 2013-02-05T08:04:37Z 2013-02-05T08:04:37Z 2012-09-18
dc.description 6 pages, 4 figures, submitted en_US
dc.description.abstract The optimal shapes attained by contractile cells on adhesive substrates are determined by the interplay between intracellular forces and adhesion with the extracellular matrix. We model the cell as a contractile film bounded by an elastic cortex and connected to the substrate via elastic links. When the adhesion sites are continuously distributed, optimal cell shape is constrained by the adhesion geometry, with a spread area sensitively dependent on the substrate stiffness and contractile tension. For discrete adhesion sites, equilibrium cell shape is convex at weak contractility, while developing local concavities at intermediate values of contractility. Increasing contractility beyond a critical value, controlled by mechanical and geometrical properties of adhesion, cell boundary undergoes a discontinuous transition to a star-shaped configuration with cusps and protrusions, accompanied by a region of bistability and hysteresis. en_US
dc.language.iso en en_US
dc.publisher SISSA en_US
dc.relation.ispartofseries arXiv:1209.4004;
dc.title Polymorphism and bistability in adherent cells en_US
dc.type Preprint en_US
dc.subject.keyword Cell adhesion, cell shape, mechanotransduction, actin en_US
dc.miur.area 2 en_US
dc.contributor.area Physics en_US
dc.contributor.area Mathematics en_US

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